Genes Dev 20 (3) Feb 2, 2006

Genes Dev 20 (3) Feb 2, 2006

• Abaza I, O Coll, S Patalano, F Gebauer. Drosophila UNR is required for translational repression of male-specific lethal 2 mRNA during regulation of X-chromosome dosage compensation
  10.1101/gad.1363206. Genes Dev. 2006, 20 (3): 380-389
  
• Duncan K, M Grskovic, C Strein, K Beckmann, R Niggeweg, I Abaza, F Gebauer, M Wilm, MW Hentze. Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation
  10.1101/gad.1363206. Genes Dev. 2006, 20 (3): 368-379
  
• Huntzicker EG, IS Estay, H Zhen, LA Lokteva, PK Jackson, AE Oro. Dual degradation signals control Gli protein stability and tumor formation
  10.1101/gad.1363206. Genes Dev. 2006, 20 (3): 276-281
  By Anthony E. Oro group at Stanford. They showed early onset basal cell carcinoma in Keratin 5 promotor driven Gli1 and Gli2 transgenic mice. Then they rule out Gli1 degradation is mediated by lysosomal degradation by using E64 and chloroquine, therefore ubiquitin-proteasome system (UPS) was proposed. They also show DSGVEM motif (Gli1DC) mediates Gli1 degradation through bTrCP-ubiquitin ligase complex and degron DN mediates a unique Sufu- and degron DC-independent pathway. Further genetic data show removal of two destruction signals rapidly accelerates tumor induction.
  
• Jain S, M Encinas, EM Johnson, Jr., J Milbrandt. Critical and distinct roles for key RET tyrosine docking sites in renal development
  10.1101/gad.1363206. Genes Dev. 2006, 20 (3): 321-333
  
• Levine AJ, Z Feng, TW Mak, H You, S Jin. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
  10.1101/gad.1363206. Genes Dev. 2006, 20 (3): 267-275
  REVIEW. p53 IGF, AKT, and TOR are important in many cell procesess, including cell proliferation, differentiation, DNA repair.
  
• Savitsky M, D Kwon, P Georgiev, A Kalmykova, V Gvozdev. Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline
  10.1101/gad.1363206. Genes Dev. 2006, 20 (3): 345-354
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