Stem cell genes linked to Male Germ Cell Tumors
Cancer Research reported:
12p Gene Cluster Projects Male GCT Stem-Cell Phenotype
Adult male germ cell tumors (GCT) show 12p gain in ~100% of cases, but the target genes are not clearly defined. In the January 15 issue of Cancer Research, Korkola et al. report results from _expression profiling that identified differentially expressed 12p genes within 101 GCT specimens. Genes in a 200kb cluster on 12p13.31, which included the stem-cell markers NANOG, GDF3, and STELLAR, were over-expressed in embryonal carcinoma and seminoma specimens but not in other GCT subtypes. To learn more, click here.
So are those the genes invovled in the development of cancer stem cells, at least in male germ tumors? It would also be interesting to look into the role of those new discovered stem cell-related genes in regulation of stem cell behaviors.
12p Gene Cluster Projects Male GCT Stem-Cell Phenotype
Adult male germ cell tumors (GCT) show 12p gain in ~100% of cases, but the target genes are not clearly defined. In the January 15 issue of Cancer Research, Korkola et al. report results from _expression profiling that identified differentially expressed 12p genes within 101 GCT specimens. Genes in a 200kb cluster on 12p13.31, which included the stem-cell markers NANOG, GDF3, and STELLAR, were over-expressed in embryonal carcinoma and seminoma specimens but not in other GCT subtypes. To learn more, click here.
So are those the genes invovled in the development of cancer stem cells, at least in male germ tumors? It would also be interesting to look into the role of those new discovered stem cell-related genes in regulation of stem cell behaviors.
posted by Zhang at 7:45 AM
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