Zhang Lab

TJMCOAA BBS

2007-01-10T11:30:00.000-08:00

The BBS (forum) of Tongji Medical College Oversea Alumni Association (TJMCOAA) has been establish.

The link is bbs.tongjioversea.org

CANCER STEM CELLS 12/10/06

2006-12-10T11:52:00.000-08:00

Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL.
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. [ABSTRACT]
Nature. 2006 Dec 7;444(7120):761-765.

Dirks PB.
Cancer: Stem cells and brain tumours. [ABSTRACT]
Nature. 2006 Dec 7;444(7120):687-688. No abstract available.

Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA.
Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. [ABSTRACT]
Proc Natl Acad Sci U S A. 2006 Dec 6; [Epub ahead of print]

Chaichana K, Zamora-Berridi G, Camara-Quintana J, Quinones-Hinojosa A.
Neurosphere assays: growth factors and hormone differences in tumor and nontumor studies. [ABSTRACT]
Stem Cells. 2006 Dec;24(12):2851-7. Epub 2006 Aug 31.

Menendez P, Bueno C, Wang L.
Human embryonic stem cells: a journey beyond cell replacement therapies. [ABSTRACT]
Cytotherapy. 2006;8(6):530-41.

Chebotaev D, Yemelyanov A, Zhu L, Lavker RM, Budunova I.
The tumor suppressor effect of the glucocorticoid receptor in skin is mediated via its effect on follicular epithelial stem cells. [ABSTRACT]
Oncogene. 2006 Dec 4; [Epub ahead of print]

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. [ABSTRACT]
Nat Genet. 2006 Dec 3; [Epub ahead of print]

Klein WM, Wu BP, Zhao S, Wu H, Klein-Szanto AJ, Tahan SR.
Increased expression of stem cell markers in malignant melanoma. [ABSTRACT]
Mod Pathol. 2006 Nov 24; [Epub ahead of print]

Rao MS, Reddy JK.
Pancreatic stem cells: differentiation options. [ABSTRACT]
Stem Cell Rev. 2005 Sep;1(3):265-72.

Shupe T, Petersen BE.
Evidence regarding a stem cell origin of hepatocellular carcinoma. [ABSTRACT]
Stem Cell Rev. 2005 Sep;1(3):261-4.

Alison MR.
Liver stem cells: implications for hepatocarcinogenesis. [ABSTRACT]
Stem Cell Rev. 2005 Sep;1(3):253-60.

Gostjeva EV, Thilly WG.
Stem cell stages and the origins of colon cancer: a multidisciplinary perspective. [ABSTRACT]
Stem Cell Rev. 2005 Sep;1(3):243-52.

Smith GH.
Stem cells and mammary cancer in mice. [ABSTRACT]
Stem Cell Rev. 2005 Sep;1(3):215-24.

Passegue E, Weisman IL.
Leukemic stem cells: where do they come from? [ABSTRACT]
Stem Cell Rev. 2005 Sep;1(3):181-8.

Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS.
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. [ABSTRACT]
Mol Cancer. 2006 Dec 2;5(1):67 [Epub ahead of print]

PANCREATIC CANCER 12/10/06

2006-12-10T11:49:00.000-08:00

Lee EJ, Gusev Y, Jiang J, Nuovo GJ, Lerner MR, Frankel WL, Morgan DL, Postier RG, Brackett J, Schmittgen TD. [ABSTRACT]
Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer. 2006 Dec 5; [Epub ahead of print]

Dragovich T, Huberman M, Von Hoff DD, Rowinsky EK, Nadler P, Wood D, Hamilton M, Hage G, Wolf J, Patnaik A. [ABSTRACT]
Erlotinib plus gemcitabine in patients with unresectable pancreatic cancer and other solid tumors: phase IB trial.
Cancer Chemother Pharmacol. 2006 Dec 6; [Epub ahead of print]

Mudali SV, Fu B, Lakkur SS, Luo M, Embuscado EE, Iacobuzio-Donahue CA.[ABSTRACT]
Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status.
Clin Exp Metastasis. 2006 Dec 5; [Epub ahead of print]

Bianco C, Giovannetti E, Ciardiello F, Mey V, Nannizzi S, Tortora G, Troiani T, Pasqualetti F, Eckhardt G, de Liguoro M, Ricciardi S, Del Tacca M, Raben D, Cionini L, Danesi R.[ABSTRACT]
Synergistic Antitumor Activity of ZD6474, An Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, with Gemcitabine and Ionizing Radiation against Pancreatic Cancer.
Clin Cancer Res. 2006 Dec 1;12(23):7099-107.

Rao MS, Reddy JK. [ABSTRACT]
Pancreatic stem cells: differentiation options.
Stem Cell Rev. 2005 Sep;1(3):265-72.

Chu CS, Xue B, Tu C, Feng ZH, Shi YH, Miao Y, Wen CJ.[ABSTRACT]
NRAGE suppresses metastasis of melanoma and pancreatic cancer in vitro and in vivo.
Cancer Lett. 2006 Nov 29; [Epub ahead of print]

JCP 08 2006

2006-08-03T16:18:00.000-07:00

CONTENT

REVIEW
Best practice in primary care pathology: review 3
W S A Smellie, J Forth, D Bareford, P Twomey, M J Galloway, E C M Logan, S R S Smart, T M Reynolds, and C WaineJ Clin Pathol 2006; 59: 781-789. [Abstract]

Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation
C-Q Zhu, W Shih, C-H Ling, and M-S TsaoJ Clin Pathol 2006; 59: 790-800. doi:10.1136/jcp.2005.031351 [Abstract]

MY APPROACH
My approach to the interpretation of endometrial biopsies and curettings
W G McCluggageJ Clin Pathol 2006; 59: 801-812. [Abstract]

Lymphoproliferative lesions of the skin
L CerroniJ Clin Pathol 2006; 59: 813-826. [Abstract]

PAPER
The Warwick system of prospective workload allocation in cellular pathology—an aid to subspecialisation: a comparison with the Royal College of Pathologists’ system
R A Carr, D S A Sanders, O P Stores, F A Smew, M E Parkes, V Ross-Gilbertson, N Chachlani, and J SimonJ Clin Pathol 2006; 59: 835-839. [Abstract]

Nat Biotech Jun 06

2006-06-19T19:23:00.000-07:00

CONTENT

COMMENTRARY
Sense about stem cells p623 Charles G Jenningsdoi:10.1038/nbt0606-623 [Full text]

The patentability of human embryonic stem cells in Europe pp653 - 655 Gerard Porter, Chris Denning, Aurora Plomer, John Sinden & Paul Torremansdoi:10.1038/nbt0606-653 [Abstract] [Full text]

Single-cell genomics pp657 - 658 Clyde A Hutchison III & J Craig Venterdoi:10.1038/nbt0606-657 [Abstract] [Full text]

The germ of pluripotency pp663 - 664 Mito Kanatsu-Shinohara & Takashi Shinoharadoi:10.1038/nbt0606-663 [Abstract] [Full text]

PAPERS
Sequencing genomes from single cells by polymerase cloning pp680 - 686 Kun Zhang, Adam C Martiny, Nikos B Reppas, Kerrie W Barry, Joel Malek, Sallie W Chisholm & George M ChurchPublished online: 28 May 2006 doi:10.1038/nbt1214 [Abstract] [Full text]

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration pp687 - 696 Eugenio Montini, Daniela Cesana, Manfred Schmidt, Francesca Sanvito, Maurilio Ponzoni, Cynthia Bartholomae, Lucia Sergi Sergi, Fabrizio Benedicenti, Alessandro Ambrosi, Clelia Di Serio, Claudio Doglioni, Christof von Kalle & Luigi NaldiniPublished online: 28 May 2006 doi:10.1038/nbt1216 [Abstract] [Full text]

Am J Path jun 06

2006-06-01T08:24:00.000-07:00

CONTENT
COMMENTRARY
Eric P. Hoffman and Diana Escolar
Translating Mighty Mice into Neuromuscular Therapeutics: Is Bigger Muscle Better? Am J Pathol 2006 168: 1775-1778. [Full Text]

PAPERS
Hong Yu, Dong Fang, Suresh M. Kumar, Ling Li, Thiennga K. Nguyen, Geza Acs, Meenhard Herlyn, and Xiaowei Xu
Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles Am J Pathol 2006 168: 1879-1888. [Abstract]

Tianhong Li, Federica Sotgia, Magalis A. Vuolo, Maomi Li, Wan Cai Yang, Richard G. Pestell, Joseph A. Sparano, and Michael P. Lisanti
Caveolin-1 Mutations in Human Breast Cancer: Functional Association with Estrogen Receptor -Positive Status Am J Pathol 2006 168: 1998-2013. [Abstract]

Easwar Natarajan, John D. Omobono, II, Zongyou Guo, Susan Hopkinson, Alexander J.F. Lazar, Thomas Brenn, Jonathan C. Jones, and James G. Rheinwald
A Keratinocyte Hypermotility/Growth-Arrest Response Involving Laminin 5 and p16INK4A Activated in Wound Healing and Senescence Am J Pathol 2006 168: 1821-1837. [Abstract]

Joseph John Bianco, Stephen John McPherson, Hong Wang, Gail S. Prins, and Gail Petuna Risbridger
Transient Neonatal Estrogen Exposure to Estrogen-Deficient Mice (Aromatase Knockout) Reduces Prostate Weight and Induces Inflammation in Late Life Am J Pathol 2006 168: 1869-1878. [Abstract]

Mod Path jun 06

2006-05-29T08:35:00.000-07:00

CONTENT

PAPERS
Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma
Donna E Hansel, Alan K Meeker, Jessica Hicks, Angelo M De Marzo, Keith D Lillemoe, Richard Schulick, Ralph H Hruban, Anirban Maitra & Pedram ArganiMod Pathol 2006; 19 6: 772-779doi:10.1038/modpathol.3800591 Abstract

Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer
Shigeto Ueda, Kazuo Hatsuse, Hitoshi Tsuda, Sho Ogata, Nobuaki Kawarabayashi, Toshimichi Takigawa, Takahiro Einama, Daisaku Morita, Kazuhiko Fukatsu, Yoshiaki Sugiura, Osamu Matsubara & Hidetaka MochizukiMod Pathol 2006; 19 6: 788-796doi:10.1038/modpathol.3800582Abstract

Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications
Augusto Orlandi, Amedeo Ferlosio, Alessandro Ciucci, Arianna Francesconi, Beatriz Lifschitz-Mercer, Giulio Gabbiani, Luigi G Spagnoli & Bernard CzernobilskyMod Pathol 2006; 19 6: 797-803doi:10.1038/modpathol.3800586Abstract

The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas
Scott E Kilpatrick, Simon Bergman, Mark J Pettenati & Margaret L GulleyMod Pathol 2006; 19 6: 815-819doi:10.1038/modpathol.3800598Abstract

Stem cells: Good, bad and reformable

2006-05-25T20:25:00.000-07:00

Viktor Janzen and David T. Scadden
Nature 441, 418-419 (25 May 2006) doi:10.1038/441418b; Published online 24 May 2006
Yilmaz et al. (page 475) and Zhang et al. (page 518)

The ability of stem cells to continuously supply vast numbers of cells is magnificent, but it can be devastating if it runs amok, as in some tumours. So what makes a normal stem cell turn bad, and can it be redeemed?

The stem cell is a bit like the griffin of mythology — half lion, half eagle; grand and powerful, but potentially monstrous in effect. These essentially unspecialized cells can renew their own population while supplying cells that mature (differentiate) into the specialized cells necessary for all tissues. Although this ability to reproduce and self-renew is sublime when functioning properly, its disorder creates masses of dysfunctional replicating cells. Indeed, stem-cell-like cells have been found in a range of human tumours. Not all cancer is due to a stem cell gone bad, but some cancer-initiating cells are probably stem cells, and the rest acquire the stem-cell feature of self-renewal. This raises the troubling spectre that normal stem cells and cancer stem cells might share the molecular features essential to their nature. So attempting to treat cancer by disrupting the functions of the cancer stem cells might also disturb normal stem cells — potentially fatally.

J Path 209-2

2006-05-24T17:56:00.000-07:00

CONTENT

REVIEW
Trypsin in colorectal cancer: molecular biological mechanisms of proliferation, invasion, and metastasis (p 147-156) K Soreide, EA Janssen, H Körner, JPA Baak Published Online: 11 May 2006 DOI: 10.1002/path.1999 [Abstract]

PAPERS
Cardiac myxoma cells exhibit embryonic endocardial stem cell features (p 231-239) A Orlandi, A Ciucci, A Ferlosio, R Genta, LG Spagnoli, G Gabbiani Published Online: 28 Feb 2006 DOI: 10.1002/path.1959 [Abstract]

PTEN gene loss, but not mutation, in benign and malignant phaeochromocytomas (p 274-280) FH van Nederveen, A Perren, H Dannenberg, B-J Petri, WNM Dinjens, P Komminoth, RR de Krijger Published Online: 14 Mar 2006 DOI: 10.1002/path.1968 [Abstract]

Expression and regulation of human -defensin-2 in osteoarthritic cartilage (p 166-173) D Varoga, FP Paulsen, S Kohrs, S Grohmann, S Lippross, R Mentlein, BN Tillmann, MB Goldring, L Besch, T Pufe Published Online: 19 Apr 2006 DOI: 10.1002/path.1974 [Abstract]

Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach (p 190-197) SA Bleuming, LL Kodach, MJ Garcia Leon, DJ Richel, MP Peppelenbosch, PH Reitsma, JC Hardwick, GR van den Brink Published Online: 21 Mar 2006 DOI: 10.1002/path.1976 [Abstract]

Expression of drug pathway proteins is independent of tumour type (p 213-219) W Zhang, WD Shannon, J Duncan, GL Scheffer, RJ Scheper, HL McLeod Published Online: 28 Feb 2006 DOI: 10.1002/path.1955 [Abstract]

JNCI 98-10

2006-05-23T12:43:00.000-07:00

CONTENT

REVIEW/ED
Pack up Your Breast Tumor—and Grow! J Natl Cancer Inst 2006; 98: 657-659. V. Craig JordanPak [Extract]

Caring for Older Women With Breast Cancer: Can Observational Research Fill the Clinical Trial Gap? J Natl Cancer Inst 2006; 98: 660-661. Bruce E. Hillner and Jeanne Mandelblatt[Extract]

PAPERS
Caroline Holm, Suresh Rayala, Karin Jirström, Olle Stål, Rakesh Kumar, and Göran Landberg Association Between Pak1 Expression and Subcellular Localization and Tamoxifen Resistance in Breast Cancer Patients J Natl Cancer Inst 2006; 98: 671-680. [Abstract]

Benjamin D. Smith, Cary P. Gross, Grace L. Smith, Deron H. Galusha, Justin E. Bekelman, and Bruce G. Haffty Effectiveness of Radiation Therapy for Older Women With Early Breast Cancer J Natl Cancer Inst 2006; 98: 681-690. [Abstract]

Michael J. Thun, S. Jane Henley, David Burns, Ahmedin Jemal, Thomas G. Shanks, and Eugenia E. Calle Lung Cancer Death Rates in Lifelong Nonsmokers J Natl Cancer Inst 2006; 98: 691-699. [Abstract]

Jane A. Cauley, Anne McTiernan, Rebecca J. Rodabough, Andrea LaCroix, Douglas C. Bauer, Karen L. Margolis, Electra D. Paskett, Mara Z. Vitolins, Curt D. Furberg, and Rowan T. Chlebowski Statin Use and Breast Cancer: Prospective Results From the Women's Health Initiative J Natl Cancer Inst 2006; 98: 700-707. [Abstract] [Full Text] [PDF]OPEN ACCESS ARTICLE

Cell may 2006

2006-05-23T12:39:00.000-07:00

CONTENT

Only one review of my interest.
The Exosome and the Proteasome: Nano-Compartments for Degradation
Esben Lorentzen and Elena Conti[Summary]

Cancer Cell May 2006

2006-05-17T17:09:00.000-07:00

Cancer Cell May 2006 CONTENT

REVIEW
The challenges of gene expression microarrays for the study of human cancer Anna V. Tinker, Alex Boussioutas, and David D.L. Bowtell[Summary]

PAPERS
Ewing's sarcoma: General insights from a rare model Sean Davis and Paul S. Meltzer[Summary]
See also
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma Richard Smith, Leah A. Owen, Deborah J. Trem, Jenny S. Wong, Jennifer S. Whangbo, Todd R. Golub, and Stephen L. Lessnick[Summary]

PTENs
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss Qunying Lei, Jing Jiao, Li Xin, Chun-Ju Chang, Shunyou Wang, Jing Gao, Martin E. Gleave, Owen N. Witte, Xin Liu, and Hong Wu[Summary]
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans Daniel R. Carrasco, Tim Fenton, Kumar Sukhdeo, Marina Protopopova, Miriam Enos, Mingjian J. You, Dolores Divicio, Cristina Nogueira, Jayne Stommel, Geraldine S. Pinkus, Christopher Fletcher, Jason L. Hornick, Webster K. Cavenee, Frank B. Furnari, and Ronald A. DePinho[Summary]

First Atkins Professor at Univ of Mich

2006-05-17T17:07:00.000-07:00

University of Michigan Medical School obesity researcher named as U-M’s first Atkins Professor

$2 million gift from Atkins Foundation will fund metabolism research
U-M one of only seven universities receiving Atkins chairs

For more information, please visit University of Michigan News Releases.

Am J Path May 2006

2006-05-08T09:30:00.000-07:00

CONTENT

REVIEW
Cancer Interaction with the Bone Microenvironment: A Workshop of the National Institutes of Health Tumor Microenvironment Study Section Michael L. Cher, Dwight A. Towler, Shahin Rafii, David Rowley, Henry J. Donahue, Evan Keller, Meenhard Herlyn, Eun Ah Cho, and Leland W.K. Chung Am J Pathol 2006;168 1405-1412 [abstract]

PAPER
Glen Roseborough, Daqing Gao, Lei Chen, Michael A. Trush, Shaoyu Zhou, G. Melville Williams, and Chiming Wei The Mitochondrial K-ATP Channel Opener, Diazoxide, Prevents Ischemia-Reperfusion Injury in the Rabbit Spinal Cord Am J Pathol 2006 168: 1443-1451. [Abstract]

Jing-Lin Xia, Chunsun Dai, George K. Michalopoulos, and Youhua Liu Hepatocyte Growth Factor Attenuates Liver Fibrosis Induced by Bile Duct Ligation Am J Pathol 2006 168: 1500-1512. [Abstract]

Monika Kasprzycka, Miroslaw Majewski, Zhi-Jong Wang, Andrzej Ptasznik, Maria Wysocka, Qian Zhang, Michal Marzec, Phyllis Gimotty, Mark R. Crompton, and Mariusz A. Wasik Expression and Oncogenic Role of Brk (PTK6/Sik) Protein Tyrosine Kinase in LymphocytesAm J Pathol 2006 168: 1631-1641. [Abstract]

Mariana Rodríguez Zubieta, David Furman, Marcela Barrio, Alicia Inés Bravo, Enzo Domenichini, and José Mordoh Galectin-3 Expression Correlates with Apoptosis of Tumor-Associated Lymphocytes in Human Melanoma Biopsies Am J Pathol 2006 168: 1666-1675. [Abstract]

CA Stem cell inst gets OK

2006-04-28T17:06:00.000-07:00

The $3 billion California initiative for funding stem cell research got ok from California court. But the plaintiffs plan to appeal, another year wait may be necessary. The executives and scientists are extremely happy for the new anyway.

See more news coverage at Science, and MediacalNewsToday.

BW undergrad B-school ranking 2006

2006-04-28T17:00:00.000-07:00

Businessweek just cooked out their inaugural ranking list of Best undergrad B-schools. Interestingly, I found no Harvard, Yale, Columbia, Brown, or Dartmouth in the list. My guess would be that those Ivy League schools do not have a so-called undergrad business degree for undergrads, rather just a major in business. At Michigan, only select sophomores could grasp a BBA degree beared big M through 2 year study at Ross B School.

Cell Apr 21 2006

2006-04-21T07:04:00.000-07:00

Cell Apr 21, 2006

Pten, Tumorigenesis, and Stem Cell Self-Renewal Derrick J. Rossi and Irving L. Weissman 229

Searching Chromatin for Stem Cell Identity. Michael Buszczak and Allan C. Spradling REVIEW 233

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells Tong Ihn Lee, Richard G. Jenner, Laurie A. Boyer, Matthew G. Guenther, Stuart S. Levine, Roshan M. Kumar, Brett Chevalier, Sarah E. Johnstone, Megan F. Cole, Kyo-ichi Isono, Haruhiko Koseki, Takuya Fuchikami, Kuniya Abe, Heather L. Murray, Jacob P. Zucker, Bingbing Yuan, George W. Bell, Elizabeth Herbolsheimer, Nancy M. Hannett, Kaiming Sun, Duncan T. Odom, Arie P. Otte, Thomas L. Volkert, David P. Bartel, Douglas A. Melton, David K. Gifford, Rudolf Jaenisch, and Richard A. Young 301

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells Bradley E. Bernstein, Tarjei S. Mikkelsen, Xiaohui Xie, Michael Kamal, Dana J. Huebert, James Cuff, Ben Fry, Alex Meissner, Marius Wernig, Kathrin Plath, Rudolf Jaenisch, Alexandre Wagschal, Robert Feil, Stuart L. Schreiber, and Eric S. Lander 315

Cancer Research

2006-04-17T19:36:00.000-07:00

Cancer Research
Vol 66, issue 8 , Apr 2006

Meeting Report: Antiangiogenesis and Drug Delivery to Tumors: Bench to Bedside and Back Dan G. Duda Cancer Res 2006 66: 3967-3970

KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer Astrid Lièvre, Jean-Baptiste Bachet, Delphine Le Corre, Valérie Boige, Bruno Landi, Jean-François Emile, Jean-François Côté, Gorana Tomasic, Christophe Penna, Michel Ducreux, Philippe Rougier, Frédérique Penault-Llorca, and Pierre Laurent-Puig Cancer Res 2006 66: 3992-3995

Id1 Transcription Inhibitor–Matrix Metalloproteinase 9 Axis Enhances Invasiveness of the Breakpoint Cluster Region/Abelson Tyrosine Kinase–Transformed Leukemia CellsMargaret Nieborowska-Skorska, Grazyna Hoser, Lori Rink, Maciej Malecki, Plamen Kossev, Mariusz A. Wasik, and Tomasz Skorski Cancer Res 2006 66: 4108-4116

Multiple Adaptive Mechanisms to Chronic Liver Disease Revealed at Early Stages of Liver Carcinogenesis in the Mdr2-Knockout Mice Mark Katzenellenbogen, Orit Pappo, Hila Barash, Naama Klopstock, Lina Mizrahi, Devorah Olam, Jasmine Jacob-Hirsch, Ninette Amariglio, Gidi Rechavi, Leslie Ann Mitchell, Ron Kohen, Eytan Domany, Eithan Galun, and Daniel Goldenberg Cancer Res 2006 66: 4001-4010

Two-Dimensional Transcriptome Profiling: Identification of Messenger RNA Isoform Signatures in Prostate Cancer from Archived Paraffin-Embedded Cancer Specimens Hai-Ri Li, Jessica Wang-Rodriguez, T. Murlidharan Nair, Joanne M. Yeakley, Young-Soo Kwon, Marina Bibikova, Christina Zheng, Lixin Zhou, Kui Zhang, Tracy Downs, Xiang-Dong Fu, and Jian-Bing Fan Cancer Res 2006 66: 4079-4088.

Targeting Oncogenes to Improve Breast Cancer Chemotherapy Laura A. Christensen, Rick A. Finch, Adam J. Booker, and Karen M. Vasquez Cancer Res 2006 66: 4089-4094.

The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma Xiaobing Deng, Daina Z. Ewton, Sheena Li, Asghar Naqvi, Stephen E. Mercer, Steve Landas, and Eileen Friedman Cancer Res 2006 66: 4149-4158.

Development of Real-time Subcellular Dynamic Multicolor Imaging of Cancer-Cell Trafficking in Live Mice with a Variable-Magnification Whole-Mouse Imaging System Kensuke Yamauchi, Meng Yang, Ping Jiang, Mingxu Xu, Norio Yamamoto, Hiroyuki Tsuchiya, Katsuro Tomita, Abdool R. Moossa, Michael Bouvet, and Robert M. Hoffman Cancer Res 2006 66: 4208-4214.

Tumor Imaging Using a Picomolar Affinity HER2 Binding Affibody Molecule Anna Orlova, Mikaela Magnusson, Tove L.J. Eriksson, Martin Nilsson, Barbro Larsson, Ingmarie Höidén-Guthenberg, Charles Widström, Jörgen Carlsson, Vladimir Tolmachev, Stefan Ståhl, and Fredrik Y. Nilsson Cancer Res 2006 66: 4339-4348.

Characterization of a Novel Human Tumor Antigen Interleukin-13 Receptor 2 Chain Koji Kawakami, Masaki Terabe, Mariko Kawakami, Jay A. Berzofsky, and Raj K. Puri Cancer Res 2006 66: 4434-4442.

Technology transfer office

2006-04-12T19:33:00.000-07:00

More than the money Top of pageAbstractTechnology-transfer offices are learning from their mistakes. So should the academics that they serve. Nature 440, 845-846 (13 April 2006) | doi:10.1038/440845b

University challenge. Cambridge is revamping its approach to technology transfer — but will it work? Colin Macilwain reports. Nature 440, 867 (13 April 2006) doi:10.1038/440867a

Development May 2006

2006-04-12T19:23:00.000-07:00

CONTENT

Wellington V. Cardoso and Jining Lü. Regulation of early lung morphogenesis: questions, facts and controversies Development 2006 133: 1611-1624. REVIEW

Marie A. Breau, Thomas Pietri, Olivier Eder, Martine Blanche, Cord Brakebusch, Reinhardt Fässler, Jean P. Thiery, and Sylvie Dufour. Lack of ß1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype . Development 2006 133: 1725-1734.

Elaine E. Storm, Sonia Garel, Ugo Borello, Jean M. Hebert, Salvador Martinez, Susan K. McConnell, Gail R. Martin, and John L. R. Rubenstein. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers Development 2006 133: 1831-1844.

Reversal of Diabetes in Non-Obese Diabetic Mice

2006-04-07T10:05:00.000-07:00

Recently, a series of papers showed Reversal of Diabetes in Non-Obese Diabetic Mice without beta cell regeneration derived from spleen-cell or hematopoietic cells.

Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science. 2006 Mar 24;311(5768):1774-5.
PMID: 16556844 [PubMed - indexed for MEDLINE]

Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science. 2006 Mar 24;311(5768):1775-8.
PMID: 16556845 [PubMed - indexed for MEDLINE]

Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue ER. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science. 2006 Mar 24;311(5768):1778-80.
PMID: 16556846 [PubMed - indexed for MEDLINE]

Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice.Science. 2003 Nov 14;302(5648):1223-7.
PMID: 14615542 [PubMed - indexed for MEDLINE]

Stem cell update

2006-03-31T19:53:00.000-08:00

Chromatin signatures of pluripotent cell lines.Azuara V, Perry P, Sauer S, Spivakov M, Jorgensen HF, John RM, Gouti M, Casanova M, Warnes G, Merkenschlager M, Fisher AG. Nat Cell Biol. 2006 Mar 29; [Epub ahead of print]

Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Kim I, He S, Yilmaz OH, Kiel MJ, Morrison SJ. Blood. 2006 Mar 28; [Epub ahead of print]
As low as 1 HSC of fetal liver was transplanted. One out of 7.7 transplants (13%), CD48-Sca1+Lin-Mac1+ (SLM) fetal live cells gave rise to long-term multilineage reconstitution in irradiated mice, while 1 out of every 8.9 (11%) CD48-Thy(low)Sca-1(+)lineage-Mac-1(+) fetal liver cells do so. With addition of CD150, CD150+CD48-SLM cells give rise to long-term multilineage reconstitution at frequency of 30-42%. Fetal liver HSC were also found in CD41- and CD244- population. SLAM family receptors CD150, CD244, and CD48 are therefore shown enrichment markers for fetal liver HSC. The authors also emphasized the role of SLAM family receptors in distinguishing "progenitors at different stages of the hematopoiesis hierarchy and enhance the purification of definitive HSCs from diverse contexts".
Interestingly, they were not detectably expressed by stem cells in the fetal or adult nervous system.
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T. Nat Med. 2006 Mar 26; [Epub ahead of print]
In vitro germline potential of stem cells derived from fetal porcine skin. Dyce PW, Wen L, Li J. Nat Cell Biol. 2006 Mar 26; [Epub ahead of print]

Pay too much tax?

2006-03-29T17:03:00.000-08:00

It's been known that postdoc awardee of National Research Service Awards (NRSAs) receive their payments as fellowship, subject to tax exempt. However, many universities erroneously collect social security tax on them. So take a closer look at your W2! Do you overpay your tax?

Nature career has more story about it.

Nat Genet Jun

2006-03-29T09:48:00.000-08:00

Content

Adler AS, M Lin, H Horlings, DSA Nuyten, MJ van de Vijver, HY Chang. (2006) Genetic regulators of large-scale transcriptional signatures in cancer. Nat Genet 38 (4): 421-430
By Chang group

Kissler S, P Stern, K Takahashi, K Hunter, LB Peterson, LS Wicker. (2006) In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet 38 (4): 479-483
By Kissler group

Loh Y-H, Q Wu, J-L Chew, VB Vega, W Zhang, X Chen, G Bourque, J George, B Leong, J Liu, K-Y Wong, KW Sung, CWH Lee, X-D Zhao, K-P Chiu, L Lipovich, VA Kuznetsov, P Robson, LW Stanton, C-L Wei, Y Ruan, B Lim, H-H Ng. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38 (4): 431-440
By Ruan and Ng groups

Wei CL, Q Wu, VB Vega, KP Chiu, P Ng, T Zhang, A Shahab, HC Yong, Y Fu, Z Weng, J Liu, XD Zhao, JL Chew, YL Lee, VA Kuznetsov, WK Sung, LD Miller, B Lim, ET Liu, Q Yu, HH Ng, Y Ruan. (2006) A global map of p53 transcription-factor binding sites in the human genome. Cell 124 (1): 207-19
By Ng and Ruan groups

Stem cells in CELL

2006-03-28T21:17:00.000-08:00

Stem cells and cancer: two faces of eve. Clarke MF, Fuller M.Cell. 2006 Mar 24;124(6):1111-5. PMID: 16564000 [PubMed - in process]
The first publication since Mike Clarke moved to Stanford.
Connecting cancer to the asymmetric division of stem cells. Wodarz A, Gonzalez C. Cell. 2006 Mar 24;124(6):1121-3. PMID: 16564003 [PubMed - in process]
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Betschinger J, Mechtler K, Knoblich JA.
Cell. 2006 Mar 24;124(6):1241-53. PMID: 16564014 [PubMed - in process]
Stem cell research in Brazil: a difficult launch. Leite M. Cell. 2006 Mar 24;124(6):1107-9. PMID: 16563999 [PubMed - in process]