Nat Neurosci 9(3) mar 2006
Full content of Nat Neurosci 9(3)
Ramirez-Castillejo C, F Sanchez-Sanchez, C Andreu-Agullo, SR Ferron, JD Aroca-Aguilar, P Sanchez, H Mira, J Escribano, I Farinas. (2006) Pigment epithelium-derived factor is a niche signal for neural stem cell renewal. Nat Neurosci 9 (3): 331-339
Isabel Fariñas group reported Pigment epithelium–derived factor (PEDF) was secreted by components of the murine SVZ, and could promote self-renewal of neural stem cells(NSC) both in vivo and in vitro. First, they show PEDF presents in ependymal and endothelial cells, but not NSC, in adults. In vitro neurosphere formation data suggest PEDF promotes self-renewal of NSC (formation frequency of neurospheres), but not proliferation (Size of neurospheres). C-ter fragment of PEDF was then found to block effects of full-length PEDF on neurosphere formation. They demonstrate PEDF regulates NSC self-renewal in vivo by infusing PEDF and its antagonist, c-ter PEDF.
I like pharmacological evidence, that provides direct potential of clinical use.
A piece of beautiful work!
Pumiglia K, S Temple. (2006) PEDF: bridging neurovascular interactions in the stem cell niche. Nat Neurosci 9 (3): 299-300
See also commentary of Kevin Pumiglia and Sally Temple
Le Bras B, M-J Barallobre, J Homman-Ludiye, A Ny, S Wyns, T Tammela, P Haiko, MJ Karkkainen, L Yuan, M-P Muriel, E Chatzopoulou, C Breant, B Zalc, P Carmeliet, K Alitalo, A Eichmann, J-L Thomas. (2006) VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci 9 (3): 340-348
By using VEGF-C knockdown models of xenopus and mouse, Jean-Léon Thomas group demonstrates VEGF-C is required for neural development and induces proliferation of neural progenitor cells, especially VEGFR3+ ones. Briefly, VEGF-C and its receptor were first found present in the embryonic mouse brain. In vitro data suggest VEGF-C induces proliferation of neural progenitor cells derived from optic nerve, especially VEGFR3+ neural progenitor cells, while transgenic mouse lack of VEGF-C has significantly reduced oligodendrocyte precursor cells in optic nerve.
Isabel Fariñas group reported Pigment epithelium–derived factor (PEDF) was secreted by components of the murine SVZ, and could promote self-renewal of neural stem cells(NSC) both in vivo and in vitro. First, they show PEDF presents in ependymal and endothelial cells, but not NSC, in adults. In vitro neurosphere formation data suggest PEDF promotes self-renewal of NSC (formation frequency of neurospheres), but not proliferation (Size of neurospheres). C-ter fragment of PEDF was then found to block effects of full-length PEDF on neurosphere formation. They demonstrate PEDF regulates NSC self-renewal in vivo by infusing PEDF and its antagonist, c-ter PEDF.
I like pharmacological evidence, that provides direct potential of clinical use.
A piece of beautiful work!
See also commentary of Kevin Pumiglia and Sally Temple
By using VEGF-C knockdown models of xenopus and mouse, Jean-Léon Thomas group demonstrates VEGF-C is required for neural development and induces proliferation of neural progenitor cells, especially VEGFR3+ ones. Briefly, VEGF-C and its receptor were first found present in the embryonic mouse brain. In vitro data suggest VEGF-C induces proliferation of neural progenitor cells derived from optic nerve, especially VEGFR3+ neural progenitor cells, while transgenic mouse lack of VEGF-C has significantly reduced oligodendrocyte precursor cells in optic nerve.
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