Genes & Dev 20(5)

Genes & Dev 20(5) Mar 1, 2006

Covello KL, J Kehler, H Yu, JD Gordan, AM Arsham, C-J Hu, PA Labosky, MC Simon, B Keith. (2006) HIF-2{alpha} regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth 10.1101/gad.1399906. Genes Dev. 20 (5): 557-570
M. Celeste Simon Group reports HIF-2 alpha, but not HIF1, induces Oct-4 expression and impaired embryonic development. It was also found that HIF2 alpha induced tumorigenesis may attribute to dis-regulation of stem cell function through activation of Oct-4.

Gocheva V, W Zeng, D Ke, D Klimstra, T Reinheckel, C Peters, D Hanahan, JA Joyce. (2006) Distinct roles for cysteine cathepsin genes in multistage tumorigenesis 10.1101/gad.1407406. Genes Dev. 20 (5): 543-556

Hallstrom TC, JR Nevins. (2006) Jab1 is a specificity factor for E2F1-induced apoptosis 10.1101/gad.1345006. Genes Dev. 20 (5): 613-623
By using a yeast two-hybrid screen, Joseph R. Nevins group identified Jab1 as a protein that binds the E2F1 marked box and flanking regions. Further work shows Jab1 synergizes with E2F1 to induce apoptosis, but not to promote cell cycle entry.

Valencia-Sanchez MA, J Liu, GJ Hannon, R Parker. (2006) Control of translation and mRNA degradation by miRNAs and siRNAs
10.1101/gad.1399806. Genes Dev. 20 (5): 515-524
Good Review for mRNA regulation

Wu X, F Quondamatteo, T Lefever, A Czuchra, H Meyer, A Chrostek, R Paus, L Langbein, C Brakebusch. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin
10.1101/gad.361406. Genes Dev. 20 (5): 571-585
Cord Brakebusch group found absence of small GTPase Cdc42 increased degradation of beta-catenin through decreased phosphorylation of GSK3 at Ser 9 and increased phosphorylation of axin, and involved in differentiation of hair follicle progenitor cells in vivo.