Nat Cell biol 8(3)
Nat Cell biol 8(3) Mar 2006
Kaji K, IM Caballero, R MacLeod, J Nichols, VA Wilson, B Hendrich. (2006) The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. 8 (3): 285-292
Brian Hendrich group found another gene that regulates pluripotency of Embryonic Stem Cells(ESC), which is Mbd3-a component of the nucleosome remodelling and histone deacetylation (NuRD) complex. Mbd3-deficient ESC could grow in the absence of LIF, and differentiate in embryonic bodies or chimeric embryos with loss of terminal differentiation commitment.
Sirbu IO, G Duester. (2006) Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. 8 (3): 271-277
Ioan Ovidiu Sirbu & Gregg Duester demonstrate that retinoic-acid signalling is uniform across the left–right axis and occurs in node ectoderm but not node mesoderm. Retinoic acid rescue data show retinoic-acid signaling targets on node ectoderm and posterior neural plate during somitogenesis, but not presomitic mesoderm.
Brian Hendrich group found another gene that regulates pluripotency of Embryonic Stem Cells(ESC), which is Mbd3-a component of the nucleosome remodelling and histone deacetylation (NuRD) complex. Mbd3-deficient ESC could grow in the absence of LIF, and differentiate in embryonic bodies or chimeric embryos with loss of terminal differentiation commitment.
Ioan Ovidiu Sirbu & Gregg Duester demonstrate that retinoic-acid signalling is uniform across the left–right axis and occurs in node ectoderm but not node mesoderm. Retinoic acid rescue data show retinoic-acid signaling targets on node ectoderm and posterior neural plate during somitogenesis, but not presomitic mesoderm.
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