JCS 119(5) Mar 2006
Content of JCS 119(5)
Park K-S, SH Jeon, S-E Kim, Y-Y Bahk, SL Holmen, BO Williams, K-C Chung, Y-J Surh, K-Y Choi. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS 10.1242/jcs.02779. J Cell Sci 119 (5): 819-827
Knock-out data suggest APC inhibits ERK by acting on beta-catenin, with evidence that co-expression of APC reduces activation of Raf1, MEK and ERK kinases by {beta}-catenin. Also, APC over-expression decreases mutated RAS, another upstream regulator of ERK. Thus, APC may activate both RAS and beta-catenin in its regulation of cell processes.
Anitei M, M Ifrim, M-A Ewart, AE Cowan, JH Carson, R Bansal, SE Pfeiffer. (2006) A role for Sec8 in oligodendrocyte morphological differentiation 10.1242/jcs.02785. J Cell Sci 119 (5): 807-818
Over-expression and knock-down data show excyst component Sec8 promotes oligodendrocyte morphological differentiation and myelin-like membrane formation. Sec 8 was also found to directly interact with the major myelin protein OSP/Claudin11 and CASK, which may implicate its role in the diff of oligodendrocyte.
Baudry A, Z-Z Yang, BA Hemmings. (2006) PKB{alpha} is required for adipose differentiation of mouse embryonic fibroblasts 10.1242/jcs.02792. J Cell Sci 119 (5): 889-897
Knock-out mouse model and restoration data suggest PKB(alpha) is essential for adipose differentiation. Kruppel-like transcription factor 15 may play an role in PKB alpha induced adipogenesis, while several related genes were also identified.
Goping IS, T Sawchuk, DA Underhill, RC Bleackley. (2006) Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis 10.1242/jcs.02791. J Cell Sci 119 (5): 858-865
Granzyme B is critical in CTL-mediated apoptosis. Alpha-bubulin was identified as a novel substrate of granzyme B, by using proteomic approach and confirmed by mutation data.
Kottke MD, E Delva, AP Kowalczyk. (2006) The desmosome: cell science lessons from human diseases 10.1242/jcs.02888. J Cell Sci 119 (5): 797-806
Carteron C, A Ferrer-Montiel, H Cabedo. (2006) Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival 10.1242/jcs.02799. J Cell Sci 119 (5): 898-909
Chadborn NH, AI Ahmed, MR Holt, R Prinjha, GA Dunn, GE Jones, BJ Eickholt. (2006) PTEN couples Sema3A signalling to growth cone collapse 10.1242/jcs.02801. J Cell Sci 119 (5): 951-957
Chera S, R de Rosa, M Miljkovic-Licina, K Dobretz, L Ghila, K Kaloulis, B Galliot. (2006) Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype 10.1242/jcs.02807. J Cell Sci 119 (5): 846-857
Knock-out data suggest APC inhibits ERK by acting on beta-catenin, with evidence that co-expression of APC reduces activation of Raf1, MEK and ERK kinases by {beta}-catenin. Also, APC over-expression decreases mutated RAS, another upstream regulator of ERK. Thus, APC may activate both RAS and beta-catenin in its regulation of cell processes.
Over-expression and knock-down data show excyst component Sec8 promotes oligodendrocyte morphological differentiation and myelin-like membrane formation. Sec 8 was also found to directly interact with the major myelin protein OSP/Claudin11 and CASK, which may implicate its role in the diff of oligodendrocyte.
Knock-out mouse model and restoration data suggest PKB(alpha) is essential for adipose differentiation. Kruppel-like transcription factor 15 may play an role in PKB alpha induced adipogenesis, while several related genes were also identified.
Granzyme B is critical in CTL-mediated apoptosis. Alpha-bubulin was identified as a novel substrate of granzyme B, by using proteomic approach and confirmed by mutation data.
posted by Zhang at 8:03 AM
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