Reading of the week
Science
--Retraction of Hwang et al., Science 308 (5729) 1777-1783. Retraction of Hwang et al., Science 303 (5664) 1669-1674. Science 311, 335Interestingly, the first 2004 paper still has 7 authors refused to admit frauds. Maybe, the dog was real.
--Chromosomes Can Congress to the Metaphase Plate Before Biorientation
See Science 20 January 2006, 311, 388 - 391 and commentary. New wine in old bottle. Mitosis was further elucidated with the combination of live imaging system, molecular biology and chemical biology. Not my expertise, so no further comments.
--Sampling the Antibiotic Resistome Science 20 January 2006: 311, 374 - 377 A new some-ome. With the completion of Human Genome Project, Wright GD established a new one, namely antibiotic resistome. This paper gave us an early warning of antibioltic resistance. Out of 480 sampled microbes, very one of them was found resistant to 6-8 different antibiotics and some to as many as 20. See also perspective.
Nature
--New publishing rule on Cloning Nature 439, 243 (19 January 2006)
1.Mitochondrial DNA fingerprint comparison should be submitted to Nature, in addition to nuclear DNA FP.
2.If new ESC was established, one must compare its nuclear DNA fingerprint with existing ESC lines.
3.No independent verification is required, but be ready! Maybe Nature will ask for it in RARE cases.
4.To deposit to ATCC? Nature is weighing this reqirement.
--Sea of change. Nature 439, 256-260 (19 January 2006)
--Blue faculty Nature 439, 254 (19 January 2006).
AAMC new study suggests faculty members in med schools of US have as many as 1 of 5 depression symptoms. Young members and physicians have more chances.
--Scientific publishing: Peer review, unmasked. Nature 416, 258-260 (21 March 2002)
Open access peer review? Some new journals are experimenting this new way of paper evaluation. Given the competitiveness of biomedical fields, no big journals plan to adapt this open access peer review system.
--Cancer biology: Signatures guide drug choice. Nature 439, 274-275 (19 January 2006)
---Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (19 January 2006)
Joseph R. Nevins group at Duke showed deregulated oncogenic pathways differed in tumor types and correlated with clinical outcomes.
--- BRAF mutation predicts sensitivity to MEK inhibition Nature 439, 358-362 (19 January 2006) by Neal Rosen group at MSKCC.
They compared the sensitivities to ERK inhibitors in cancer cell lines with mutations of BRAF and RAS, both in vitro and in vivo. Addiontal mechanism was edemonstrated including loss of D-cylcin expression, Rb physphorylation, and G1 arrest induced by ERK inhibitor.
--A brain-specific microRNA regulates dendritic spine development Nature 439, 283-289 (19 January 2006) by Michael Greenberg group.
--Retraction of Hwang et al., Science 308 (5729) 1777-1783. Retraction of Hwang et al., Science 303 (5664) 1669-1674. Science 311, 335Interestingly, the first 2004 paper still has 7 authors refused to admit frauds. Maybe, the dog was real.
--Chromosomes Can Congress to the Metaphase Plate Before Biorientation
See Science 20 January 2006, 311, 388 - 391 and commentary. New wine in old bottle. Mitosis was further elucidated with the combination of live imaging system, molecular biology and chemical biology. Not my expertise, so no further comments.
--Sampling the Antibiotic Resistome Science 20 January 2006: 311, 374 - 377 A new some-ome. With the completion of Human Genome Project, Wright GD established a new one, namely antibiotic resistome. This paper gave us an early warning of antibioltic resistance. Out of 480 sampled microbes, very one of them was found resistant to 6-8 different antibiotics and some to as many as 20. See also perspective.
Nature
--New publishing rule on Cloning Nature 439, 243 (19 January 2006)
1.Mitochondrial DNA fingerprint comparison should be submitted to Nature, in addition to nuclear DNA FP.
2.If new ESC was established, one must compare its nuclear DNA fingerprint with existing ESC lines.
3.No independent verification is required, but be ready! Maybe Nature will ask for it in RARE cases.
4.To deposit to ATCC? Nature is weighing this reqirement.
--Sea of change. Nature 439, 256-260 (19 January 2006)
--Blue faculty Nature 439, 254 (19 January 2006).
AAMC new study suggests faculty members in med schools of US have as many as 1 of 5 depression symptoms. Young members and physicians have more chances.
--Scientific publishing: Peer review, unmasked. Nature 416, 258-260 (21 March 2002)
Open access peer review? Some new journals are experimenting this new way of paper evaluation. Given the competitiveness of biomedical fields, no big journals plan to adapt this open access peer review system.
--Cancer biology: Signatures guide drug choice. Nature 439, 274-275 (19 January 2006)
---Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (19 January 2006)
Joseph R. Nevins group at Duke showed deregulated oncogenic pathways differed in tumor types and correlated with clinical outcomes.
--- BRAF mutation predicts sensitivity to MEK inhibition Nature 439, 358-362 (19 January 2006) by Neal Rosen group at MSKCC.
They compared the sensitivities to ERK inhibitors in cancer cell lines with mutations of BRAF and RAS, both in vitro and in vivo. Addiontal mechanism was edemonstrated including loss of D-cylcin expression, Rb physphorylation, and G1 arrest induced by ERK inhibitor.
--A brain-specific microRNA regulates dendritic spine development Nature 439, 283-289 (19 January 2006) by Michael Greenberg group.
posted by Zhang at 7:29 AM
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