Mod Path jun 06

CONTENT

PAPERS
Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma
Donna E Hansel, Alan K Meeker, Jessica Hicks, Angelo M De Marzo, Keith D Lillemoe, Richard Schulick, Ralph H Hruban, Anirban Maitra & Pedram ArganiMod Pathol 2006; 19 6: 772-779doi:10.1038/modpathol.3800591 Abstract

Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer
Shigeto Ueda, Kazuo Hatsuse, Hitoshi Tsuda, Sho Ogata, Nobuaki Kawarabayashi, Toshimichi Takigawa, Takahiro Einama, Daisaku Morita, Kazuhiko Fukatsu, Yoshiaki Sugiura, Osamu Matsubara & Hidetaka MochizukiMod Pathol 2006; 19 6: 788-796doi:10.1038/modpathol.3800582Abstract

Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications
Augusto Orlandi, Amedeo Ferlosio, Alessandro Ciucci, Arianna Francesconi, Beatriz Lifschitz-Mercer, Giulio Gabbiani, Luigi G Spagnoli & Bernard CzernobilskyMod Pathol 2006; 19 6: 797-803doi:10.1038/modpathol.3800586Abstract

The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas
Scott E Kilpatrick, Simon Bergman, Mark J Pettenati & Margaret L GulleyMod Pathol 2006; 19 6: 815-819doi:10.1038/modpathol.3800598Abstract

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Stem cells: Good, bad and reformable

Viktor Janzen and David T. Scadden
Nature 441, 418-419 (25 May 2006) doi:10.1038/441418b; Published online 24 May 2006
Yilmaz et al. (page 475) and Zhang et al. (page 518)

The ability of stem cells to continuously supply vast numbers of cells is magnificent, but it can be devastating if it runs amok, as in some tumours. So what makes a normal stem cell turn bad, and can it be redeemed?

The stem cell is a bit like the griffin of mythology — half lion, half eagle; grand and powerful, but potentially monstrous in effect. These essentially unspecialized cells can renew their own population while supplying cells that mature (differentiate) into the specialized cells necessary for all tissues. Although this ability to reproduce and self-renew is sublime when functioning properly, its disorder creates masses of dysfunctional replicating cells. Indeed, stem-cell-like cells have been found in a range of human tumours. Not all cancer is due to a stem cell gone bad, but some cancer-initiating cells are probably stem cells, and the rest acquire the stem-cell feature of self-renewal. This raises the troubling spectre that normal stem cells and cancer stem cells might share the molecular features essential to their nature. So attempting to treat cancer by disrupting the functions of the cancer stem cells might also disturb normal stem cells — potentially fatally.

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J Path 209-2

CONTENT

REVIEW
Trypsin in colorectal cancer: molecular biological mechanisms of proliferation, invasion, and metastasis (p 147-156) K Soreide, EA Janssen, H Körner, JPA Baak Published Online: 11 May 2006 DOI: 10.1002/path.1999 [Abstract]

PAPERS
Cardiac myxoma cells exhibit embryonic endocardial stem cell features (p 231-239) A Orlandi, A Ciucci, A Ferlosio, R Genta, LG Spagnoli, G Gabbiani Published Online: 28 Feb 2006 DOI: 10.1002/path.1959 [Abstract]

PTEN gene loss, but not mutation, in benign and malignant phaeochromocytomas (p 274-280) FH van Nederveen, A Perren, H Dannenberg, B-J Petri, WNM Dinjens, P Komminoth, RR de Krijger Published Online: 14 Mar 2006 DOI: 10.1002/path.1968 [Abstract]

Expression and regulation of human -defensin-2 in osteoarthritic cartilage (p 166-173) D Varoga, FP Paulsen, S Kohrs, S Grohmann, S Lippross, R Mentlein, BN Tillmann, MB Goldring, L Besch, T Pufe Published Online: 19 Apr 2006 DOI: 10.1002/path.1974 [Abstract]

Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach (p 190-197) SA Bleuming, LL Kodach, MJ Garcia Leon, DJ Richel, MP Peppelenbosch, PH Reitsma, JC Hardwick, GR van den Brink Published Online: 21 Mar 2006 DOI: 10.1002/path.1976 [Abstract]

Expression of drug pathway proteins is independent of tumour type (p 213-219) W Zhang, WD Shannon, J Duncan, GL Scheffer, RJ Scheper, HL McLeod Published Online: 28 Feb 2006 DOI: 10.1002/path.1955 [Abstract]

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JNCI 98-10

CONTENT

REVIEW/ED
Pack up Your Breast Tumor—and Grow! J Natl Cancer Inst 2006; 98: 657-659. V. Craig JordanPak [Extract]

Caring for Older Women With Breast Cancer: Can Observational Research Fill the Clinical Trial Gap? J Natl Cancer Inst 2006; 98: 660-661. Bruce E. Hillner and Jeanne Mandelblatt[Extract]

PAPERS
Caroline Holm, Suresh Rayala, Karin Jirström, Olle Stål, Rakesh Kumar, and Göran Landberg Association Between Pak1 Expression and Subcellular Localization and Tamoxifen Resistance in Breast Cancer Patients J Natl Cancer Inst 2006; 98: 671-680. [Abstract]

Benjamin D. Smith, Cary P. Gross, Grace L. Smith, Deron H. Galusha, Justin E. Bekelman, and Bruce G. Haffty Effectiveness of Radiation Therapy for Older Women With Early Breast Cancer J Natl Cancer Inst 2006; 98: 681-690. [Abstract]

Michael J. Thun, S. Jane Henley, David Burns, Ahmedin Jemal, Thomas G. Shanks, and Eugenia E. Calle Lung Cancer Death Rates in Lifelong Nonsmokers J Natl Cancer Inst 2006; 98: 691-699. [Abstract]

Jane A. Cauley, Anne McTiernan, Rebecca J. Rodabough, Andrea LaCroix, Douglas C. Bauer, Karen L. Margolis, Electra D. Paskett, Mara Z. Vitolins, Curt D. Furberg, and Rowan T. Chlebowski Statin Use and Breast Cancer: Prospective Results From the Women's Health Initiative J Natl Cancer Inst 2006; 98: 700-707. [Abstract] [Full Text] [PDF]OPEN ACCESS ARTICLE

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Cell may 2006

CONTENT

Only one review of my interest.
The Exosome and the Proteasome: Nano-Compartments for Degradation
Esben Lorentzen and Elena Conti[Summary]

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Cancer Cell May 2006

Cancer Cell May 2006 CONTENT

REVIEW
The challenges of gene expression microarrays for the study of human cancer Anna V. Tinker, Alex Boussioutas, and David D.L. Bowtell[Summary]

PAPERS
Ewing's sarcoma: General insights from a rare model Sean Davis and Paul S. Meltzer[Summary]
See also
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma Richard Smith, Leah A. Owen, Deborah J. Trem, Jenny S. Wong, Jennifer S. Whangbo, Todd R. Golub, and Stephen L. Lessnick[Summary]

PTENs
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss Qunying Lei, Jing Jiao, Li Xin, Chun-Ju Chang, Shunyou Wang, Jing Gao, Martin E. Gleave, Owen N. Witte, Xin Liu, and Hong Wu[Summary]
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans Daniel R. Carrasco, Tim Fenton, Kumar Sukhdeo, Marina Protopopova, Miriam Enos, Mingjian J. You, Dolores Divicio, Cristina Nogueira, Jayne Stommel, Geraldine S. Pinkus, Christopher Fletcher, Jason L. Hornick, Webster K. Cavenee, Frank B. Furnari, and Ronald A. DePinho[Summary]

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First Atkins Professor at Univ of Mich

University of Michigan Medical School obesity researcher named as U-M’s first Atkins Professor

$2 million gift from Atkins Foundation will fund metabolism research
U-M one of only seven universities receiving Atkins chairs

For more information, please visit University of Michigan News Releases.

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Am J Path May 2006

CONTENT

REVIEW
Cancer Interaction with the Bone Microenvironment: A Workshop of the National Institutes of Health Tumor Microenvironment Study Section Michael L. Cher, Dwight A. Towler, Shahin Rafii, David Rowley, Henry J. Donahue, Evan Keller, Meenhard Herlyn, Eun Ah Cho, and Leland W.K. Chung Am J Pathol 2006;168 1405-1412 [abstract]

PAPER
Glen Roseborough, Daqing Gao, Lei Chen, Michael A. Trush, Shaoyu Zhou, G. Melville Williams, and Chiming Wei The Mitochondrial K-ATP Channel Opener, Diazoxide, Prevents Ischemia-Reperfusion Injury in the Rabbit Spinal Cord Am J Pathol 2006 168: 1443-1451. [Abstract]

Jing-Lin Xia, Chunsun Dai, George K. Michalopoulos, and Youhua Liu Hepatocyte Growth Factor Attenuates Liver Fibrosis Induced by Bile Duct Ligation Am J Pathol 2006 168: 1500-1512. [Abstract]

Monika Kasprzycka, Miroslaw Majewski, Zhi-Jong Wang, Andrzej Ptasznik, Maria Wysocka, Qian Zhang, Michal Marzec, Phyllis Gimotty, Mark R. Crompton, and Mariusz A. Wasik Expression and Oncogenic Role of Brk (PTK6/Sik) Protein Tyrosine Kinase in LymphocytesAm J Pathol 2006 168: 1631-1641. [Abstract]

Mariana Rodríguez Zubieta, David Furman, Marcela Barrio, Alicia Inés Bravo, Enzo Domenichini, and José Mordoh Galectin-3 Expression Correlates with Apoptosis of Tumor-Associated Lymphocytes in Human Melanoma Biopsies Am J Pathol 2006 168: 1666-1675. [Abstract]

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